Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction

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Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction

Alzheimer's disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function. We tested the hypothesis that there is ...

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ژورنال

عنوان ژورنال: International Journal of Alzheimer's Disease

سال: 2013

ISSN: 2090-8024,2090-0252

DOI: 10.1155/2013/623241